eLife

Evidence of off-target probe binding affecting 10x Genomics Xenium gene panels compromise accuracy of spatial transcriptomic profiling

Computational assessment identifies probe binding errors in a widely used commercial platform for spatial transcriptomics.
The Scientist

Scaling Up Spatial Transcriptomic Technologies to Organs

Fei Chen and Chenlei Hu at the Broad Institute of MIT and Harvard have developed a new imaging-free spatial transcriptomics technology that tracks the diffusion of DNA barcodes between beads in an ...
eLife

A spatiotemporal transcriptomic atlas of the mouse placenta reveals glycogen cell-mediated metabolic support essential for fetal viability

This valuable study reports a spatiotemporal atlas of mouse placental development and explores the role of glycogen trophoblast cells in fetal viability. Solid data are presented to support the main ...
Frontiers

Microglial Dynamics in Alzheimer's: Genetic Variants and Therapeutic Pathways

Microglia are pivotal players in the neuroinflammatory landscape of Alzheimer’s disease (AD). Accumulating evidence underscores their complex role in ...